OSTEOARTHRITIS AND CHOLESTEROL
Osteoarthritis a painful condition especially at the joints are caused by high cholesterol which triggers mitochondrial oxidative stress within the cartilage and neuronal tissues and ganglia, a result of a new research study.
New research published in the FASEB journal online in animal models found that high cholesterol triggers mitochondrial oxidative stress on cartilage cells causing them to degrade and die leading ultimately to the development of osteoarthritis.
Antioxidants targeting mitochondrial oxidative stress can be a suitable treatment for cholesterol-induced osteoarthritis.
Indira PrasadamPh.D.a researcher from the Institute of Health and Biomedical Innovation, School of Chemistry, Physics, and Mechanical Engineering at the Queensland University of Technology in Brisbane, Australia, said that we have already started working with various dietitians to give proper public education about eating a healthy diet free from bad cholesterols in order to save them from mitochondrial oxidation of cartilage tissues.
In general the research found that bad cholesterols are not only harming the cardiovascular system but their traps extending to extra C.V systems such as neuronal and skeletal systems.
The researches used two sets of animal models for the study. The first model was a mouse model in which an altered gene called ApoE-/- was induced to induce hypercholesteremia.
The other was a rat model that was fed with controlled cholesterol food to produce diet-induced hypercholesteremia and among them some were treated with cholesterol-lowering drugs atorvastatin and some were given with antioxidants. Both the models were subjected to surgery to mimic knee injuries to produce osteoarthritis. Later they found the mouse models with altered genes and high cholesterol were developed rapidly osteoarthritis than those were given with normal controlled diet and those with cholesterol-lowering treatments and those with antioxidants. This because of the high cholesterol which triggers mitochondrial oxidation of bone cartilage cells.
Include antioxidants in our diets are always advisable especially after forty years in order to get rid of the painful osteoarthritis.
