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DO YOU KNOW?-3

DO YOU KNOW?-3
CREATININE CHEMISTRY

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Sunday, 4 September 2016

NEWS UPDATE-COFFEE AND CAFFEINE

COFFEE AND CAFFEINE

It has been found out that occasional coffee drinking is riskier than regular coffee drinking. A research was carried out with a group of occasional coffee drinkers and another group of regular coffee drinkers.
The result has shown those occasional coffee drinkers because of the deep fluctuation of the concentration of caffeine in their blood are prone to have higher risks of blood pressure and other cardiovascular complications.300 ml of black coffee consumption can elevate blood pressure within two hours and last for several hours. Hence a drink of coffee may affect the blood pressure measurement results if it was consumed just before the B.P. measurements by the occasional drinkers.
Also coffee drinking by occasional drinkers may interfere with their B.P.medications, such as calcium channel blockers.
Research has shown that Felodipine a calcium channel blocker used to reduce the B.P when used along with a cup of coffee has elevated the B.P. instead of reducing it.
These are because in occasional coffee drinkers the concentration of caffeine deeply fluctuates even if they drink the coffee with a two days gap.
After a cup of coffee the caffeine concentration remains in the blood for two days only. Within two days the blood is almost cleaned off most of the caffeine content. Then by another drink of coffee at the end of the second-day caffeine reenter into the blood as a fresh candidate and may have all its effects freshly. Hence a drink of coffee on every alternate day too are considered as occasional drinks and the body cannot tolerate caffeine as with the regular drinkers.
Regular daily drinking of coffee will be tolerated by the body and the maintenance of a fixed concentration of caffeine in the blood may not complicate blood pressure and other cardiovascular irregularities.

AUTOCOIDS AND ANTAGONISTS-PART-4

AUTOCOIDS AND THEIR ANTAGONISTS

Contd...

Ergot Alkaloids:-

1.Bromocriptine
2.Ergonovine
3.Ergotamine
These products are not endogenous substances and hence they are not true autocoids. They are alkaloids of ergot fungi. Yet they are discussed here because of their important actions on smooth muscles as similar to autocoids.
Ergot alkaloids are a group of compounds produced by the fungus Claviceps purpurea.
Ergot alkaloids are mainly acting on adrenergic, serotonergic, and dopamine receptors.

Physiology:-

1.Hallucinations and delusions on overdoses
2.Psychoses and neuro problems on higher doses
3.Vasoconstrictions
4.Uterine stimulation

Therapeutical Use

 

1. Ergotamine is used to treat migraine by reducing cerebrovascular pulsations
2. Bromocriptine is used to treat hyperprolactinemia
3. Ergotamine and Ergonovine is used to control postpartum hemorrhage
 Side Effects
1.Gangrene due to prolonged vasoconstriction which can be reversed by sodium nitroprusside.
2.Diarrhea
3.Nausea and vomiting
4.Unintentional uterine contractions
5.CNS psychoses.

 

BRAIN MAPPING

BRAIN MEANDERING PATHWAY                                                                         Maturity, the thinking goes, comes with age...