AUTOCOIDS AND THEIR ANTAGONISTS
Contd...
Ergot Alkaloids:-
1.Bromocriptine
2.Ergonovine
3.Ergotamine
These products are not endogenous substances and hence they are not true autocoids. They are alkaloids of ergot fungi. Yet they are discussed here because of their important actions on smooth muscles as similar to autocoids.
Ergot alkaloids are a group of compounds produced by the fungus Claviceps purpurea.
Ergot alkaloids are mainly acting on adrenergic, serotonergic, and dopamine receptors.
Physiology:-
1.Hallucinations and delusions on overdoses
2.Psychoses and neuro problems on higher doses
3.Vasoconstrictions
4.Uterine stimulation
Therapeutical Use
1. Ergotamine is used to treat migraine by reducing cerebrovascular pulsations
2. Bromocriptine is used to treat hyperprolactinemia
3. Ergotamine and Ergonovine is used to control postpartum hemorrhage
Side Effects
1.Gangrene due to prolonged vasoconstriction which can be reversed by sodium nitroprusside.
2.Diarrhea
3.Nausea and vomiting
4.Unintentional uterine contractions
5.CNS psychoses.
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