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DO YOU KNOW?-3

DO YOU KNOW?-3
CREATININE CHEMISTRY

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Friday 28 May 2021

DRUGS AND THEIR SIDE-EFFECTS

Medications and side effects 

((Disclaimer: - The information included on this site is for educational purposes only and is not intended for medical treatment.)

Fig-1

All medications can cause unwanted side effects. Medications include prescription drugs, over-the-counter medications, and complementary medications (herbal products and vitamins).
The formula ingredients on the drug label may ‘collide’ with each other. Therefore, taking more than one medication at a time may increase the risk of side effects.
About 230,000 Australians are hospitalized each year due to drug problems, including side effects. Most side effects are manageable, some are very serious and can even cause death.
Managing your medications wisely is in your best interests.
Doctor prescription drugs:-
Generally, any medicine should be bought on the recommendation of a doctor. Self-medication is very dangerous. Even so, alcohol users should not take any medication on their own. This is because some antibiotics can cause unwanted side effects with alcohol
Vitamins if not through food, are all toxic when they are available as store-bought medicines,  including herbal medicines. 
Remember,  medications including vitamins available as store-bought drugs are all poisons.
 They are chemicals.
The following medications should not be taken without a doctor's prescription.
1.Antibiotics 
2. Anxiolytics
3. Antidepressants
4. Antipsychotics
For example, some antibiotics cause allergic reactions in up to five percent of the population. Psoriasis is a common reaction. But it is not always easy to tell if it is caused by a reaction, medication, or disease.
In addition, some antibiotics can cause drug-drug interactions between them and other drugs.
For example, 
It is now common to take the antibiotic azithromycin for soar-throat and cough without a doctor's prescription. This azithromycin can cause unwanted side effects with digoxin used for heart disease. Azithromycin itself can rarely cause severe cardiac arrhythmias.
People with potassium and magnesium deficiency and severe diarrhea caused by C.difficile infection should not be given azithromycin without a doctor's prescription.
People taking antibiotics, especially erythromycin or clarithromycin, are generally advised to avoid the following allergy medications.
1. Terfenadine
2.Astemizole
3.Ketazole-an anti-fungal
The reason is that these compositions can cause damages to the heart.
Generally, do not take all fluoroquinolones, such as ciprofloxacin or ofloxacin, without a doctor's prescription. They can affect your kidneys. can cause crystalluria. Do not take the following medications with them.
1. Theophylline, an asthma drug
2. Probenecid a drug for hyperuricemia and gout.
3. Glibenclamide, a diabetic drug
4. NSAID painkillers such as Aspirin, Diclofenac  Aceclofenac, Brufen, and Naproxen.

Sleeping Pills - Drug Interactions with Sleeping Aids:-

Sleeping pills are available without any control as like ubiquitous vitamin pills, and people now buy and eat. It doesn't matter how old the doctor's prescription is. It is freely available at the pharmacy counters without any restrictions.
Attention Alprazolam Sleeping Pill Eaters. These drugs can cause drug interactions if they are taken with the following drugs.
1. Carbamazepine used for epilepsy
2. Cimetidine used for ulcers
3. Clarithromycin
4.Erythromycin
5.Grapefruit and its juice.
6.Alcohol and heroin
7.All psychiatric medications
Generally, caution should be exercised when taking any benzodiazepine drugs such as Alprazolam, Clonazepam, and Diazepam.
Because of these
1. Closed-Angle Glaucoma may occur
2. Shortness of breath may occur.
3. Epilepsy may occur
4. Liver/kidney may be damage
5. Depression and suicidal thoughts may be produced.
6. Diphenhydramine Diphenhydramine Codeine Phosphate Cough tonics should not be taken with sleeping pills. These compositions can lead to respiratory depression, hypoxia, and eventually death.

Grapefruit: -
Fig-2

This fruit is a very healthy nutritious fruit. It has a lot of vitamin C and is a boon for diabetics. It is very low in sugar. Stimulating tissue use of insulin. Very low in calories.
However, this fruit can cause reactions when taken with most medicines.
Drugs that cause reactions while eating this fruit: -
1. Cholesterol drugs Simvastatin and Atorvastatin.
2. Nifidipin, a heart disease drug
3. Cyclosporin, which is given to prevent the body from rejecting organs when they are transplanted.
4. Sleeping pills especially Buspirone
5. Budanoside, a corticosteroid used by some patients with peptic ulcers, and asthma.
6. Amiodarone, a drug that can be given for heart disease (irregular heartbeat). 
Grapefruit can prevent the above drugs from being properly metabolized. So those drugs can accumulate in large quantities in the body and cause great harm.
7. Fexofenadine is an allergy drug. Even if you take the right amount of this medicine, the grapefruit will prevent it from being absorbed properly by the intestines. This because grapefruit blocks the absorption of the fexofenadine carrier protein by the small intestine (See Fig-2 above)
Finally, your health is in your hands. It can only be partially attributed to doctors and pharmacists. If not, you may fall into the deep hole (see Figure-1)


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