HOW TO IDENTIFY ECG WAVES?-ECG EDUCATION-E

ECG-NOMENCLATURE

In this article we are going to study how to identify a particular wave among the important five waves namely P, Q, R, S, T.

At any time when we examine the ECG we should always note that the first wave of the heartbeat as shown in the figure should be identified as P-waves. The P-waves appear in many forms as shown below.

FIG-1

The above figure (Fig-1) note that the P-waves are in different forms. Except for the first one all three are abnormal P-waves. At the last abnormal P-wave, the P-wave is almost absent.
As we already studied from the last posts about ECG that the P-wave represents the contraction (depolarization)of the upper chambers (Atria) of the heart. Hence any irregular abnormal P-waves are seen in the ECG then it means there are problems in any one of the atria or both. If there is a conical shaped apex in the P-wave (Fig-1-1st abnormal) it means the right atrium is enlarged.
If there is an M-shaped apex in the P-wave (2nd abnormal in Fig-1) it means the left atrium is enlarged.
If the P-wave is overlaid on the baseline, disappeared, or almost absent(3rd abnormality-Fig-1) then  SA nodal blockade and atrial fibrillation must be suspected. In atrial fibrillation the P-wave is replaced by tiny irregular f-waves.
The next wave follows is the Q-wave which forms a part of the important QRS-complex.
The Q-wave can be defined in two ways.
1.Q-wave is the wave with a minute or large negative deflexion following the P-wave. or
2. The Q-wave can be defined as the wave with a small or large negative deflection which is immediately followed by the R-wave.In other words 
Any negative deflection whether it is small or large immediately before R-wave should be identified as Q-wave or 'q'-wave if it is small 
QRS-Nomenclature
As we know that the QRS-complex is the main part of the ECG so we should deal with a special for it as follows:-
Three things we must keep in our minds.
1.Position of the waves
2.Nature of deflection (+ or -)
3.Size of the deflection.
See the following figures Fig-2; and Fig-3.Fig-4; and Fig-5.

Fig-2
A normal QRS

See the above Fig-2 a normal QRS complex is displayed.

Fig-3

In the above figure (Fig-3)there is a typical QRS complex is displayed. Sometimes we come across such complicated ECGs to identify the waves.
In such cases we should always devise a common theory which states that in any QRS- complex the first negative deflection immediately before the R-waves must be named as Q or q-waves depending upon the size of the deflection. If there are more than one it should be quoted with ' (prime)
Note in the above figure (Fig-3) the Q-wave is absent as there is no first negative deflection before R-wave.
Secondly in any QRS complex any first positive deflection within the complex should be named as R or r waves with ' (prime) if there are more than one according to its sizes.
See the following another typical QRS.

Fig-4

Thirdly any first negative deflection immediately after the R-wave is the S or s waves with '(prime)
if more than as per its sizes.
In the above figure (FIG-4) again there are no Q-waves. But there are 2 consecutive positive deflections represents two R-waves (R, R') immediately followed by two consecutive negative deflections named as S and S'.
Then the nomenclature of the T-wave which represents the relaxation of the ventricles.

Fig-5

In the above figure note the position deflection of the T-wave. After the T wave, after the ventricular relaxation there is no electrical conduction up to the next cycle started by the SA-node the pacemaker. Hence the interval T-P is the perfect and absolute iso electrical line to be kept for reference.
                    Continued in next post(F)

ECG EDUCATION--D

THE 12 LEAD ECG MACHINE

In the market ECG machines are available in various types such as 12-lead,6-lead,3-lead, and single lead types.

When we think to buy one for our home use we must first familiar with these types.

For example when we buy a 12-lead machine we should have a thorough knowledge regarding the number of electrodes (Leads) and what are the functions of each electrode and how they should be placed on our body.

See the following animated diagram for a 12-lead ECG machine:-            

                             

Fig-1

In Fig-1 we can see the various electrodes and how they are placed on a human body and brief details are given below:-

1.aVR-Lead:-This lead has been attached at the wrist below the palm at the right hand.

2.aVL-Lead:-This lead has been attached on the left-hand wrist similarly.

3.aVF(R)-Lead:-This lead has been attached at the right foot which you can see as a red dot at the right foot without naming as it serves merely as an earth connection without any further involvement in the ECG procedure.

4.aVF-Lead:-This is attached on the left foot similar to the right.

The above mentioned three unipolar leads namely aVR,aVL, and aVF are forming a triangle known as Einthoven's Triangle.

The above-mentioned triangle is shown with green lines in the above figure.

The triangle is very important as it adds three more virtual bipolar electrodes namely lead-I,

lead-II, and lead-III (Limb bipolar electrodes)

5. In the above diagram (Fig-1) the lead-I receives electrical signals from aVR, and aVL and sends it to the heart.

6. Similarly, the lead-II receives signals from the two unipolar leads namely aVR and aVF and send to the heart

7. The last bipolar lead receives signals from aVL and aVF and sends it to the heart.

Now we attached 7 electrodes out of which one is earth (aVR-F) and the three bipolar electrodes are virtual and embedded in each side of the triangle.

Now we have to place six more electrodes known as chest electrodes as per the methods given below:-
V1-electrode:4th intercostal space at the right sternal border. This means from the first rib next to the shoulder bone (clavicle) below the neck to the space between 4th and 5th ribs and right to the chest big bone(sternum)
V2-electrode:-Similar to the above lead but to the right of the sternum.
V3-electrode:-Midway between V2 and V4.
V4-electrode:-5th intercostal space at the midclavicular line
V5-electrode:-Left anterior axillary line horizontally next to V4.
V6-electrode:-Left midaxillary line on the same horizontal pane next to V4 and V5.
Now the views of the heart by the electrodes are diagrammatical as follows:-

                                 Fig-2 In the above diagram (Fig-2) there are three views such as from the anterior(upper), posterior(lower), and lateral(side) views.
aVR, I,aVL, V1, V2, V3 are viewing the heart from the upper side.
aVF is viewing the heart from the lower side
II, III, V4'V5'and V6 are viewing from the lateral sides.
Terminology:-
Electrodes-----Electrical conductor or receiver
Lead         ---- The electrical potential difference                              between two electrodes
aVR------Augmented Voltage Right

aVL ------Augmented Voltage Left
aVF ------Augmented Voltage Foot

Note:-Many times these two terms 'lead and electrode' are used interchangeably and it doesn't matter.
The bipolar electrodes are virtual and hence they are leads only.

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                                                           Continued in the next post (E)...

ECG EDUCATION-C-ECG AXIS

AXIS OF HEART ON ECG

The axis of the heart in the ECG is the main direction of the overall electrical conductions of the heart. It is very easy to assess the QRS axis which is the electrical depolarization of the ventricles. Since the total mass of the ventricles represents 90% of the total mass of the heart assessing the QRS axis can give us the knowledge of almost all of the heart problems. The QRS axis can be easily observed at the lead-II column because the lead II is fixed very near to the ventricles. This column is separately mentioned at the bottom as the last column in the ECG paper
P-axis may give us some figures for the problems in the atrium only which is 1/8 that of the heart problems.
Hence we are going to concentrate more on the QRS axis in the following article.

Normally all the electrical activities of the heart are directed towards -30 degrees to +90 degrees in a quadrant as shown in the diagram below:-

Fig-1

In the above diagram (Fig-1) the circle has been divided with two crossed pairs of diameters perpendicular to each other to form 4 main quadrants.
For the illustrative purposes these 4 quadrants have been subdivided into sub-quadrants with 30 degrees radians each.
In Fig-1 if the axis (Yellow) is shifted to the left (-30 to -90) then it is known as Left Access Deviation (LAD) which indicates that there are problems in the left ventricle such as hypertrophy or a fascicular block.
Similarly if the axis is shifted to the right side then it is known as Right Access Deviation (RAD) which indicates there are problems in the right ventricle.
Normal ECG:- In the above circle (Fig-1) the leads I, II, and aVF lie in the normal yellow region. Hence in the ECG graph if the QRS complex is positive in the lead-I and II column and aVF column then we can confirm that the ECG is normal with normal ventricular depolarization and the axis of the electrical activities are normal.
Abnormalities:- In the above circle aVL lies on the quadrant between -30 to -90 degrees.
Hence in the ECG columns of lead-I and aVL shows positive QRS and column aVF shows negative QRS then there is LAD which indicates there are problems in the left ventricle.
Similarly if column I shows negative QRS, and the columns of aVF and the III-lead shows positive QRS then there is RAD.
If both column I and aVF shows negative QRS then there is an indeterminate axis which means extreme deviation. 

How to be Familiar With ECG Columns

                             

Fig-2

See the above graph. When you have received your ECG report you may notice on your ECG graph which will look like the one shown above. (Fig-2)
Descriptions as follows:-
1)I-column:-This shows the deflection QRS by the I-bipolar electrode or lead
2)II-column:-This shows the QRS axis deflected in the II-bipolar electrode or lead
3)III-column:- This shows the QRS-axis deflected in the III-bipolar electrode or lead.
4)aVR column:-This shows the QRS deflection at the aVR-unipolar lead.
5)aVL-column:-This shows the QRS axis deflected at the aVL-unipolar lead.
6)aVF-column:-This shows the QRS axis deflected at the aVF-unipolar lead
7)V-1 column: This shows the QRS deflection at the 1st chest lead
8)V-2-column:- This shows the QRS deflection at the 2nd chest lead.
9)V-3-column:-This shows the QRS deflection at the 3rd chest lead.
10) V-4-column:-This shows the QRS deflection at the 4th chest lead.

11)V-5-column:-This shows the QRS deflection at the 5th chest lead.
12)V-6-column:-This shows the QRS deflection at the 6th chest column.

                                                Continued next...

ECG ABNORMALITIES-ECG EDUCATION-B

ECG ABNORMALITIES

Before we go into the subject we must observe some parameters in the ECG.

AXIS OF THE ECG

The axis of the ECG is the major direction of the overall electrical conductions of the heart.

This we can see in the next post in detail.

First of all we must know about the columns in the ECG.

There are 12 columns in your ECG chart. Ignore the first three columns namely 1) aVR- V1- V4; 2)aVL- V2- V5; 3)aVF- V3- V6.

Note the last column which is Sinus Rhythm or Lead II- column. 

In this column you can observe three things namely normal sinus rhythm, sinus bradycardia, and sinus tachycardia. Any of the last two if present then your ECG is abnormal.

Fig-1

1. Normal Sinus Rhythm:-(See Fig-1)

In this the heart rate is normal (60 to 100 bpm), all R-R intervals are equal in length.

The P- wave appear normal (not over 2.5 mm or 2.5 ss)in height, and (not more than 0.12 sec or 3ss) in width. The P-wave represents the two upper chambers (Atria) contraction (Atrial Depolarization)
The QRS complex which represents the contraction of the lower chambers (Ventricular Depolarization)

The P-R interval is the length at the beginning of the upslope of the P-wave to the beginning of the QRS complex and normally it must be 0.12 to 0.20 seconds or 3 to 5 ss.

The normal duration of the QRS complex must be between 0.08 to 0.1 sec or 2 to 2.5 ss.

The amplitude of the R-wave in the sinus rhythm-II column should not be more than 20mm or less than 4 LS.
The QT interval(From the beginning of the Q-wave to the apex of the T-wave should not be more than 2 large boxes or 0.4 sec.
The ST interval fits and overlaps over the isoelectric line and its length is not over 0.08 sec or 2ss.

2. Sinus Bradycardia:-(See Fig-1)
    This can be identified from the ECG by calculating the HR which is <50 BPM.
The RR intervals are elongated
If still the waves are regular then it may not be worried and it may be temporary conditions due to lack of body movements.

3. Sinus Tachycardia:-(See Fig-1)
    This can be identified by calculating the HR which is above 130 BPM. Again if the waves are regular then this too not to be worried as it may be due to over activities such as sports, exercises or work overloads

PATHOLOGICAL OR ABNORMAL ECG 

Fig-2

1.Atrial Fibrillation(See Fig-2)

Examine the P-wave and the PR interval

In atrial fibrillation the P wave is almost absent or invisible and the QRS complexes are irregular as shown in the diagram above. (Fig-2)
Clinical Symptoms of A-fib:-
1.Palpitations with feelings of difficulties with racing flip-flap speed of the heartbeat.
2.Tiredness and weakness
3.Headache
4.Breath short
5.Chest tightness and pain
Atrial fibrillation also occurs if there is Sinoatrial Exit Block means the conduction is blocked and cannot exit out of SA node. A prolonged SA node exit block (III degree block) can cause cardiac arrest.
Some times or infrequently if there is a negative U-shape deflection that immediately follows the T-wave and if it is prominent then it means there is suspected hypokalemia (low potassium), or hypercalcemia(high calcium) or hyperthyroidism.
2. Atrial Flutter:-(See Fig-2)
In Atrial flutter the ECG shows many P-waves as in the diagram.
In atrial flutter the atrium is stimulated irregularly by the SA node.
Clinical symptoms of A-Flutter:-
Very similar to A-fib with less severity.
3.AV CONDUCTION BLOCK
There are three degrees of AV conduction blocks.
The symptoms are as follows:-
1. The heart rate slows down
2. Some times it may not be worried but many times it may be fatal.
3. In the ECG the P-R intervals are elongated to such a limit after which the P-wave and R-waves have no connections at all and the condition is the third-degree AV block.
4.Irregular Heartbeats
5.Syncope and dizziness
6.Chest pain.

Fig-3

4. Ventricular Tachycardia:-(See Fig-3)

Ventricular Tachycardia is the fast heart rhythm with ventricles contracting and relaxing very fast and equal to exceed 100 bpm. Because of ventricles' fast actions the atrial actions are masked and hence there are no visible P-waves. The heartbeat is so fast so that it has fewer chances to be filled with blood.
In VT randomly any two or three beats may be normal with clear P and T waves.
Symptoms of V.T:-
1.Neck tightening
2.Palpitations
3.Nausea and vomiting
4.Headache
6.Dizziness
5. Ventricular Fibrillation:-(See Fig-3)
Ventricular fibrillation is very similar to ventricular tachycardia but more serious than VT because in V.F the ventricles beat irregularly and faster than in VT and incoordinate to fill in and pump out the blood.VF if not treated immediately may lead to cardiac arrest and death.
Symptoms vary similar to VT.
6.Atrial Enlargements:-(See Fig-3)
From the ECG the appearance of the P-wave will indicate the presence of enlargements on either or both the atria. (see the diagram above)
The cone-shaped P-wave apex may indicate there is an enlargement in the right upper chamber (right atrium) 
Causes and symptoms:-
1. The tricuspid valve which is in between the right atrium and ventricle may be damaged.
2.Due to right ventricular failure.
3.Pulmonary hypertension -High pressure in the pulmonary artery.
4.Breathing difficulties
5.Palpitations
6.Arrhythmias
The M-shaped P-wave apex is the indicator of left atrial enlargement 
Causes and Symptoms:-
1.Due to the mitral valve regurgitation, stenosis, and damage
2.Left ventricle failure
3.High B.P
4.Atrial fibrillation
5.Heart failure
6.Fluid build-up and weight gain
7.Breathing difficulties
8.Palpitations.
7.Myocardial Infarction (Heart Attack)(Fig-3)
The ECG changes are as follows:-
1.T-waves are elevated (Hyperacute T-waves)
2.Elevated ST intervals
3.Followed by negative T-wave deflection
4. Finally negative large deflection of Q-wave occurs.
Ischemia develops due to a block of blood circulation and oxygen supply to a portion of the heart muscles. If this ischemia is mild and reversible the can recover its coronary blood supply.
But if the ischemia is severe and irreversible then heart cells will die which leads to MI.
Symptoms Of MI
1.severe, and crushing chest pain
2.Sweating due to sympathetic stimulation
3.Vomiting
4.Shock with decreased B.P, paleness, panic, weak pulse
5. Arrhythmias followed by ventricular fibrillation and collapse.

                                                   Continued...

ECG EDUCTION-A-ECG BASIC-

ECG INTERPRETATIONS

An ElectroCardioGram or ECG (more frequently as  EKG in which K replaces C which represents the first letter of the German word 'Kardio') is the testing of electrical conductions through the heart muscles (Myocardium) which describes the regular 'SINUS RHYTHMs' and the heartbeats in the form of line waves which can be recorded graphically.

In this article we can study all the basics of how to interpret the ECG.

Fig-2

All ECGs are recorded in graph papers that contain large and small squares. Every large square is composed of five small squares. These squares represent seconds.

Each small squares are 1 m.m in width horizontally by which we can calculate the width of the large squares as 5 mm horizontally.

The horizontal axis (the X-axis) represents time. Every 1mm square in the X-axis(the time axis) represents 0.04 seconds and every large square represents 0.04 x 5⇔0.20 seconds.

The above calculations are based on the ECG machine speed which is set up to move the ECG paper by 25 mm per second.
The vertical Y-axis represents the electrical conductions that can be recorded in millivolts and which are in the form of positive and negative deflections.
The positive deflection is the one which deflects upward and above the isoelectric line-the X-axis.
On the contrary the negative deflection is the one which goes down below the isoelectric line.
An isoelectric line is the one in which there are no deflections or electric conductions and that is a brief resting position in between two conduction cycles and that is usually represented by the T-P interval which we will understand in due course.
Again the vertical Y-axis contains the dependent variable the cardiac electric deflections in millivolts which can be calculated as follows.
On a standard ECG paper a deflection of the pointer above or below the isoelectric line with 10 small squares represents + or - 1 mV provided that each small square has a width of 1mm.
That is 10mm above or below deflection =+ or - 1mV.
From a normal ECG we can study so many important health parameters including arrhythmias and other heart problems such as atrial fibrillation, atrial flutter, ventricular fibrillation, myocardial infarction(MI), heart rate, normal sinus rhythm, sinus bradycardia, and sinus tachycardia etc.etc.
A normal adult heartbeat is 80 to 100 bpm. (beats per minute)
The normal range is from 70 to 100 bpm.
For a newborn baby it may be between 90 to 160.
A beat or rhythm is a full ventricular depolarization or contraction, which is the systole represented by the QRS complex in the ECG graph. The QRS is followed by a brief gap to another small bump deflected above the isoelectric line which is the T-wave.The T- wave is the end of one full sinus rhythm.T-wave represents the ventricular repolarization or relaxation.
T-P interval is the resting interval in which no conduction which represents the isoelectric line. The isoelectric line goes until the next cycle begins at P-wave which represents the atrial depolarization, the diastole.
To calculate the heart beats per minute you have to do the followings:-
We already know that the speed of the ECG is 25mm per sec. That means,
                            1 sec   = 25 mm
                            60 sec = 25X60=1500 mm
 Hence 1 min =1500 mm or 1500 small squares
We know that 5 small squares constitute one large square and hence in one minute 300 large squares are moved in the ECG. Count the number of R-waves which represent the heart rate per minute by this 300 sq.method.This 300 is the magic number that we can use to find out our heart rate in the standard large square method. There is another method known as a 6-sec method which we will see later.
            Before we perform any of the above two methods we must confirm that the ECG is normal with regular sinus rhythms. To do this first you take an empty white strip of a paper. overlap the strip exactly to coincide with the ECG and mark with a pen any one of the completed sinus rhythms or any of the two consecutive R-R intervals to find out all R-R gaps are equal to each other. This can be done by overlap the mark upon one by one of the following R-R intervals. If the mark fits exactly on all the R-R intervals then we can say the ECG is normal with regular sinus rhythm.
Now we can proceed with the large square method to determine the heart or pulse rate.
Method-1:-The Large Square Method:-
Spread your ECG on the table.
Count the number of large squares between any two consecutive R-R intervals.
Divide 300 by this number,
The result is your heart beats per minute.
Method-2-The Six seconds Method:-
In this method the ECG must be taken in a 6-second strip paper. Note that there are three lines on the upper part of the strip for every 6 seconds. Count the number of R-waves within these 3 lines  (6 sec) and multiply the number by ten which gives the heartbeats per minute.
This method is useful even if your ECG is not normal.
The 6-second gap can also be calculated as follows:-
Assuming that the speed of the ECG is 25mm/sec.
Accordingly we already noticed that in one minute 300 large squares have passed.
hence                                 1 min = 300 large sq.
                                    (ie) 60 sec= 300 large sq
                              then for 6 sec = 30 large sq
Hence mark down the gap which includes 30 large squires.
Now count the number of R-waves within this gap and multiply it by 10 which will yield the heart rate in beats per minute.

General Nomenclature of an ECG:-

In this section we can find the naming of the ECG parts.

Normally an ECG is appearing like this.

    

Fig-3

In the above diagram we can observe various conductions and their relationships with a normal ECG.

The electrical responses of the various parts of the heart muscle can be classified briefly as follows:-

0-Phase:-In this phase sodium ion flows inwards rapidly into the myocardial cell and depolarizes it the muscle contracted which is represented by elevation in the graph (see diagram)

1-Phase: -A short but powerful drop-in which all sodium ion gates closed and there is a powerful outflow of potassium ion from the cell with the exchange for the chloride ion which flows into the cell and the myocardium repolarizes and relaxes (note in the above diagram this phase is absent in SA and AV nodal conductions.)This phase is present only in the Purkinje fibers that are the ventricular response. This means the ventricles after a shoot up contraction undergo a brief relaxation which can be evidently seen in the ECG as S-wave at the QRS complex.

2-Phase:-This is the phase very prominent and important in the electrophysiology of the heart. In this there is a continuous potassium ion efflux and calcium ion influx to form a plateau in the cardiogram. In the above diagram you can notify this plateau as the S-T interval in ECG.

3-Phase:-In this phase the calcium ion gates are closed and continuous efflux of potassium ion. This is the rapid repolarization or relaxation of the ventricles which can be seen in the ECG as T-waves.

4-Phase:-This is diastolic depolarization in which the ventricles are ready for another cycle. The resting phase is maintained by continuous potassium efflux and slow sodium and calcium ion influx. This is represented in the ECG as the isoelectric line.

FIG-4

At the beginning of the heartbeat first the conduction starts at the SA (Sinoatrial)- node which is situated at the top right corner of the right atrium (right upper chamber) of the heart. Sinoatrial node is the pacemaker to start the heart rhythm. It spontaneously depolarizes with a slow response and spread the electrical conduction to the left atrium and down to the ventricles.

The diaphragm which separates the atria from the ventricles is totally inert and will not respond to electrical conduction. Hence the conduction from the SA node goes to the AV node directly.

But before it reaches the ventricles the conduction is paused for a while by the AV (atrioventricular) node which briefly takes time to decides to send the conduction down to the lower chambers are not. This is represented in the ECG as the P-R or P-Q interval. The AV node is situated at the left bottom of the right atrium and just above and very near to the center of the two ventricles.

Up to the AV node the muscle responses to the conduction are slow in order to give enough time to the AV node to decide.

Once the AV-node comes decided it responds quickly and passes the conduction to the Bundle of His, which is situated at the top-bottom junction of the two ventricles or at the inferior end of the internal septum to the ventricles. (See the figure-4 above)

The bundle of His quickly responds to the conduction and passes it to its branches on either side. The branches then pass it quickly and finally to the Purkinje Fibers which holds the two ventricles. The conduction passes to the ventricular muscles which depolarize quickly and powerfully contract with a sound 'dup'.The ventricular contraction is the powerful one that overshadows the atrial repolarization or relaxation. The ventricular contraction is represented by the QRS complex which masks the atrial relaxation in the ECG. You can note from the above figure the QRS complex is the main part of an ECG which exactly at the overshoot region of the Purkinje fiber (ventricular) response drawn above the ECG (See Fig-3 above)

Now we will go back to the P-wave the first part of the ECG.

From the above figure (Fig-3) the P-wave is the region represented by the atrial contraction(depolarization) which is slow and deflect to a small part just above the isoelectric line (X-axis or Time-axis)

We have already seen that the atrial relaxation (repolarization) is masked in the QRS complex.

Now come to the end portion which is the T-wave in the ECG. The T-wave represents ventricular relaxation (repolarization).

We can summarise these waves as follows:-

1.P-wave-Atrial contraction

2.P-Q interval-A brief pause at the AV-node

3.Q-wave-The brief preparation of the ventricular muscles to overshoot

4.R-Wave-Ventricular Contraction, the overshoot phase.

5.S-wave-after the systole brief repolarization followed by a diastolic depolarization to reach the isoelectric line.

6.S-T-interval-The resting phase before the ventricle relaxes.

7.T-wave:-Repolarization of the ventricles followed by the diastolic depolarization of the atria for the next P-wave cycle.

8.T-P interval-The The isoelectric line.

A brief Terminology:

1.Depolarization-means contraction of the muscles

2.Repolarization-means relaxation of the muscle.

3.Systole-Ventricular contraction (atrial relaxation)-R-wave (QRS -Complex)

4.Diastole-Atrial contraction -P-wave

5.Ventricular relaxation-T- wave

                                          Continued in the next 

A brief explanation regarding to 'Depolarization' and 'Repolarization'.

MELATONIN-HORMONE OF SLEEP-CORRECTING SLEEP DISORDERS

  SLEEP DISORDERS AND TREATMENTS

                           A good night's sleep indicates that our body is in good health.

Insomnia is the condition in which a person is hardly getting sleep.

Generally, our brain controls all activities of our body including wake and sleep.

The pineal gland is an endocrine situated deep in the centre of the two halves of our brain.

Melatonin is synthesized by the pineal gland from the neuronal excitatory hormone known as 5-hydroxytryptophan (5HT3) or serotonin. Melatonin is chemically known as N-acetyl-5-methoxy tryptophane or roughly be called as acetyl methoxy tryptophane.

Melatonin is not a sleeping medicine like some antihistamines, gabaergic, or anticholinergic. But it helps a person to fall asleep by induction and regulating sleep patterns like the circadian clock.

When darkness fell the room our natural circadian rhythm reaches the mood of asleep. This is induced by our third eye known as the pineal gland by releasing melatonin into our blood.

Melatonin helps our body to identify the time for sleep when lights went off and darkness gets in.

Melatonin helps our body to prepare for sleep by relaxation, decreased respiration, and body temperature, yet it is not a sleeping drug. Melatonin does not keep you dull or sleepy.

When the sun rises in the morning our eyes detect light and our third eye the pineal gland reduces the secretion of melatonin. Melatonin preparations are available in the market as food supplements.

One can use it with the following precautions. Because overdosage and overtime use may produce side effects.

Melatonin can be used safely for 1 year for continuous use. After that one should put at least a three-month gap.

Melatonin can be dosed from 05 to 10 milligrams according to the person's needs.

05 mg may give a person to sleep for 1 hour while 10 mg may give you 7 to 10 hours of sleep. A low dose is always safe.

Melatonin is having other advantages also such as fat loss, muscle gain, improved metabolism, and muscle protection. It prevents muscle waste.

Melatonin does not keep a person asleep but it will induce sleep.

On overdose melatonin actually, reset your circadian clock and your sleep pattern will be changed.

The Science of Sleep:-

Our body has its own sense of rhythms known as circadian rhythmic cycles in a 24 hour day time. These cycles are involved by the secretions of various chemicals and activities to schedule our body's various daily programs such as what to do and when to do. These circadian cycles are actually known as the Mind in Mind. This In Mind has to be prepared or to be consulted by our mind before scheduling any program.

For example, if a person has got an engagement in the morning for that he set his alarm to wake him up at 6 o'clock in the morning. But when the alarm rings at 6 a.m the person cannot get up and his mind and mood will not cooperate with him to get up to attend the scheduled program.

This is because his mind did not consult or programmed the In Mind or the circadian clock accordingly.

Melatonin is one of the chemicals involved in the circadian rhythms to schedule our sleep time when darkness falls. Melatonin tells our body to go to bed because it is time for sleep when your bedroom becomes dark.

This circadian cycle starts from the brain's suprachiasmatic nucleus which is situated at the centre of the brain. At the sunrise in the morning when light fills the bedroom the suprachiasmatic nucleus sends circadian signals down to the spine. The body sets the program ready for the day. When the light falls on the eyes the retina sends back the signals to the suprachiasmatic nucleus which in turn commands the pineal gland to reduce melatonin release. In the evening when the light dims and darkness falls on the retina again signals go to the pineal gland through the suprachiasmatic nucleus to increase the melatonin release into the blood and the cerebrospinal fluids. The presence of melatonin attains its peak at midnight. Normal sleep starts. This is the science of sleep. Any disturbance to this science may result in normal sleep disorders.

Side Effects: -Side effects are few as follows.

1.Headache

2.Short Depression

3.Sleepiness, somnambulant

4.Dizziness

5.Stomach pain

6.Hypothermia

7.Bedwetting in Children

8.Day time drowsiness in adults.

Do not drive at least for 4 hours after taking melatonin.
Merits:-
Melatonin is safer than clonazepam in patients with Parkinson Disease
Melatonin is graded as a food supplement and not a sedative by the FDA because it works entirely in a different pathway.
Melatonin by itself is a derivative of serotonin a hormone of peace and an excitatory neurotransmitter. Sedatives and sleeping pills are working through Gamma Amino Butyric Acid (GABA) pathway which is a neuronal inhibitory pathway.
Of course, serotonin is an excitatory neurotransmitter it is not as powerful as the catecholamines and hence it is not hormone of stress.
Similarly, serotonin has some inhibitory effects on some nerve synapses but not as strong as GABA and hence it would not produce much drowsiness and sedation.
Comparisons:-
GABA-ergic sleeping medicines like benzodiazepines such as alprazolam,midazolam,nitrazepam and diazepam may cause more sedation and respiratory depressions.
GABA-ergic neuroleptics like Gabapentin, Pregabalin are all producing fatal drowsiness and sedation
In addition, all of the above drugs can cause addiction.
But melatonin is very safe and free from all the above drawbacks as it is based on serotonin

Contraindications:-
Do not take sedatives like diazepam or zolpidem with melatonin
Do not take omeprazole like PPI medicines.
Do not take anticoagulants like aspirin, clopidogrel, or warfarin along with melatonin.
Do not take diclofenac like pain killers along with melatonin.
Consult with a neuro specialist before taking this medicine.

SELF HEALTH CHECK-UP-CHECK YOUR B.P AT HOME BY YOUR SELF-II

HOW TO USE MANUAL B.P METERS

Both manual and electronic meters use oscillometric methods to measure B.P.
There are two types of manual meters
1.Aneroid
2.Mercury

But they are quite different when we handle them. Digital electronic meters are very sensitive and need many precautions to have precise readings. They need repeated measurements to get satisfactory results. But mechanical and manual meters such as mercury and aneroid meters are very convenient in handling and needless precautions to get results satisfactorily with a single measurement. In this method patient's movements do not disturb the accuracy. Albeit their easiness to handle they have their own disadvantages.

span style="font-size: x-large;">When using manual meters one should be familiar with the so-called KOROTKOFF sounds that can be heard through a stethoscope. This is the correct auscultatory method of B.P measurement.

In the following diagram there are 5 sounds that can be heard which are represented by 5 blue unequal straight lines.

During measurements distinguishing these sounds are very important to get an accurate result. This can be possible through experiences of using a stethoscope.

Method

Preparations for the measurement are similar to the electronic methods with relaxation and easiness while sitting on a chair.

The table height is not very important but it must be inconvenient.

It is not a must to keep the cuff sensor in a straight line with the heart.

1. Put the arm with fingers relaxed on the table.

2. Place the cuff around your elbow and tight it.

3. Place the bulb of the stethoscope on the brachial artery of your upper arm-elbow joint and inflate the cuff to just above your assessed systolic pressure. Allow the cuff to deflate slowly.

4. Carefully watch the five Korotkoff sounds as follows:-

          1.The first clear weak sound that slowly increases

           2.The second stronger and clear sound but still somewhat weaker than the 3rd sound.

           3.The clear strong sound that approaches the peak. At this point stop the deflation and note down the reading-Systolic Pressure.

           4. Allow to further deflate and note down the sound gets weaker and weaker

           5. The final fifth swashing and murmuring sound follows and disappears at a point. Stop the deflation and note down the reading-The diastolic Pressure

In this manual method Pulse, reading cannot be measured.