MALE HYPER GONADISM-TREATMENTS

ANTI ANDROGENIC TREATMENTS

Anti androgenic treatments are options prescribed for the treatments when androgens are over dosed and the male sex organs are over powered to precipitate so many unwanted serious and non serious side effects.

If androgens are administered carelessly without a doctor's supervision the following side effects are observed.

1.Over musculinization

2.Over virilization

3.Hirutism in women

4.Depression of menses,acne and clitoral enlargement

5.Rarely hepatic adenomas and carcinomas

6.Cholestatic jaundice

7.Prostatic hyperplasia. 

Anti Androgens

1.Gonadotropin Releasing alalogues:- Leuprolide or Gonadorelin

This drug is available as subcutaneous daily dose injection and should be prescribed by a doctor and given by him in his office.This drug resembles structurally similar to the hypothalamus gonadotropin releasing hormone and imitating it and thereby suppressing the release of gonadotropic hormone and thereby inhibiting the gonads.At the inistial state it may incease the levels of LH and FSH the two gonadotropins,but on continuation of the treatment it will suppress their levels 

Mostly used in Prostate enlargement

2.Receptor Inhibitors:- Cyproterone  Bicalutamide and Fluamide

It is a non steroidal synthetic androgen receptor blocker mostly used for treating Prostate Cancer.

Also can be used to treat hyper androgenic actiivity and hirutism in women.

 Bicalutamide is a newer medicine and because of its more convenience and lesser side effects it mostly replaces Flutamide.

3.Steroid synthesis Inhibitors:- Ketaconazle,and Spinolactone(Aldactone)

4.5-a-Reductase Inhibitors:-Dutostride and Finastride

These drugs can be taken orally according to doctor's advise.They inhibit the conversion of the less active testosterone into the more active dihydrosterone by inhibiting the enzyme 5-a-Reductase.