MIXED (DIRECT AND INDIRECT) AGONISTS
These drugs act indirectly by releasing noradrenaline from its storage as well as directly act at the receptors.
1.Ephedrine:-
Ephedrine according to its classification releases noradrenaline from its storage vesicles and thereby stimulating the adrenergic postganglionic receptors. Also, ephedrine acts directly at the receptor sites and causes sympathetic stimulation.
Uses:-
1.Urinary incontinence (Frequent and involuntary urinations)
2.Bronchospasm as in asthma or Congestive and Obstructive Pulmonary Disease, Bronchitis, Caugh, and Cold.
3.Hypotension.
Side effects:-
1.Arrhythmias
2.Palpitations
3.Insomnia
4.Hypertension
2.Metaraminol:-
Similar to ephedrine metaraminol also causes the release of noradrenaline to act on its receptors as well as itself acts directly on the receptors.
It is having an affinity adrenergic alpha receptors.
Uses:-
1.Treatment of hypotension
2. Termination of Paroxysmal Atrial Tachycardia(PAT) is a kind acute tachyarrhythmia that starts quickly at the atria and ends quickly. It is also known as Bouveret Hoffman Syndrome
Side effects:-
1.Hypertension
2.Palpitations
3.Urinary retention
4.Insomnia
5.Arrhythmias
and all other symptoms similar to that of adrenergic stimulations.
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