CENTRAL NERVOUS SYSTEM-ANXIETY-CONTINUE

CNS-ANXIETY-TREATMENTS-CONTD...

1.AZASPIRONES

Buspirone:-

Buspirone is an anxiolytic with minimum side effects with a slow onset of actions such as a minimum of 2 weeks to give apparent actions.

Mechanism:-

Buspirone unlike benzodiazepines and GABA it stimulates partially the serotonin (5-hydro tryptamine) 5-HT-1A receptor which by partial agonism produces calmness.

Uses

For generalized anxiety with minimum side effects because of its slow onset of action and lack of withdrawal symptoms.

Metabolism:-

The drug is metabolized in the liver and excreted by kidneys.

I have a moderate duration of action as its half-life is 11 hours maximum.

It differs from benzodiazepines by the lack of muscle relaxant action and anticonvulsant properties.

It cannot be used like diazepam for seizures and epilepsy.

Side effects:-

1.Headaches

2.Nausea

3.Vomiting

Advantages:-

1.Less sedation

2.Low drug abuse potential

3.No overdosage fatalities

4.No withdrawal symptoms

2.CARBONATES:-

Meprobamate:-

Its mechanism of action is unknown.

These medicines totally out of use in the medical field because of its serious side effects.

Side effects:-

1.Respiratory Depression-very serious

2.Hypotension

3.Shock

4.Heart Failure.