When should you worry about your headaches?

 Migraine - One Side Headache

Headache is one of the most common symptoms in the world. For some, headaches are caused by factors such as hunger or stress. Sometimes these go away on their own. So about these are not to be worried.

But other headaches, such as migraines, can be very serious.

Migraines can sometimes cause malaise and fatigue and weaken the body, but for some people, confusion with visual auras in the eyes and sensitive auras in the ears may be a sign that they are at a much higher risk - the risk of stroke is very high.

How migraines vary

Migraines are often described as throbbing or throbbing like a thunderbolt in the skull, but they can be dull or stressful, or sharp. They often occur in the middle of the head or in a specific area, but sometimes cover the entire head, and they can sometimes move from one side of the head to the other.

A visual aura is a visual or emotional impairment that may or may not precede a single headache. Visual scattering is very common and is often described by incandescent lamps as light arches, light bow shapes, colors, or shaped parts. Sometimes visual symptoms may include blackheads or total or partial vision loss.

Sensory aura is the feeling of tingling or numbness in light scattering. It starts small and spreads to large areas of the face or joints. Difficulty in understanding or expressing the characteristics of other radii, which may include difficulties such as limb weakness or imbalance on one side.

Risk of Migraine and Stroke

According to a 2016 study published in the British Medical Journal, people who experience aura with a single headache have a double risk of having a stroke.

Being a woman smoker under the age of 45 and being on contraceptives further increases the risk of stroke.

Women with migraines with photosensitivity have a significantly increased risk of stroke. What do you need to know about preventing stroke?

Some studies have shown that it has a potential association with migraines, lightheadedness, and heart disease.

It is not yet clear whether treating and preventing migraines can reduce the risk of stroke, but women who use estrogen in the form of contraceptives or hormone therapy should be cautious as smoking should be stopped and the role of estrogen in blood clotting is high. As pregnancy increases the production of estrogen, women with migraines should be taught about their high-risk levels.

In addition, certain auras associated with migraine may reflect symptoms of a stroke. Stroke is caused by a blockage in the blood vessels of the brain or bleeding in the brain.

In fact, experts say that without a clinical evaluation and testing of the patient's correct disease and treatment history, it is difficult for some patients to distinguish between stroke and migraine.

When to see a doctor

Individuals who experience persistent headaches should see a neurologist for a thorough evaluation and examination because an accurate diagnosis is important for effective treatment - Expert's opinion.

Excessive stress headaches and some mild migraines can be treated with relaxation, relaxation, and over-the-counter (OTC) medications or painkillers. Acute migraine headaches may require migraine treatments.

Frequent Headaches - Tension, migraines, or other types of primary headaches may require preventive treatment with daily medication.

Red signals of headache

Some headaches are considered "red flags" because they can cause symptoms in a basic, life-threatening condition. If you experience any of these symptoms, consult a specialist.

1) - Suddenly, a severe headache reaches unbearable intensity from seconds to more than minutes. This is sometimes referred to as a thunderstorm headache. This can cause life-threatening bleeding in the space between the brain and you should go to the emergency room immediately.

2) -A new headache that has not been experienced before, or an increase in severity, or a lack of regular effective treatment

3) -The headache that wakes you up at night.

4) -Coughing, sneezing, or weight gain during headaches 

5) -New headaches after the age of 40 when you have never had a headache before.

6) -with any symptoms such as headache, weakness in the face, arms, or legs; Numbness or coordination problems; Vision disorder; Language or speech problems; Giddiness; Mess; Altered awareness; Or seizures. If those symptoms occur, go for emergency treatment.

(If you have a comment or an alternative opinion to this article please post your comments in the comment box below)

ADULT MALE AND PROSTATE GLAND

 Prostate Health

(Prostate gland and its effects only on men.

Read this pamphlet and follow the specific methods in it, especially the eating habits.

Useful for all men over 40)

Benign Prostate Hyperplasia (BPH) or, in simpler terms, harmless prostate enlargement. Useful article/talk about this neoplastic condition. Also, this can be classified into a kind of harmless neoplasm. The main part of the control mentioned in this article is food, food can be brought under our control and it will definitely be beneficial.

Is this the Wrong title? Is the prostate definitely for men?

Yes, for men only. Men over the age of 40 are especially prone to prostate enlargement. But this health enlightenment article is common to all.

Mainly concerning health promotion. 

Responsible health promotion should provide three things:-

1. Information

2. Commitment

3. Action Plan.

Let’s start with the background of prostate health:-

Everyone has a pair of kidneys. The job of the kidney is to remove waste. It is an important waste management company for your body. Your blood is filtered through the kidneys several times each day. As the blood is filtered, urine is formed and stored in a temporary storage tank called the bladder.

 If without only there is no bladder, when a man walks on the road, the urine will continue to flow.

Now think of plumbing work in your home. Consider the bladder as an overhead storage tank.

From the storage tank, a good plumber will lay the pipes to other parts of the house, including the kitchen. In the same way, the miraculously wise plumber, God has set up a tube from our bladder to the tip of the penis based on his wisdom. That tube is called the urethra. A small organ below the bladder and around the urethra is called the prostate gland.

The prostate gland is the size of a walnut and weighs about 20 grams. Its job is to produce semen. The fluid is stored in the SEMINAL VESICLES.

After the age of 40, the prostate gland begins to enlarge under the influence of a type of hormone called di-hydro testosterone, which is converted from testosterone secreted from the male sex organs the testes. This conversion is performed by the prostate itself. The prostate can grow from 20 grams to almost 100 grams. As it gets bigger, it compresses the urethra. So man begins to feel changes in the way he urinates.

Terminal Dripping:

Even after urinating, the man begins to notice urine flowing in his pants. After an old man urinates, this is why he has to ring the bell. A younger man simply drips off to the last drop. Look at an old man coming out of the bathroom. Sometimes he would hold the newspaper close to cover urine stains, especially to cover the stains on normal colored trousers.

Reluctance

You may have to wait a long time for urine to start flowing at this point. You need to open 2 valves to urinate - inner and outer loops. Both are open but you have to wait a long time for the urine to come out as there are obstructions in the urethra.

Inability to urinate completely

You have this feeling as soon as you urinate.

 When all of this happens, the bladder begins to work harder to compensate for the blockage in the urethra. The frequencies of urination increase. The water begins to tighten. Sometimes you have to run to the toilet. Nocturia also becomes common during this problem. You wake up more than 2 times a night to urinate. Your wife starts to complain.

Men not being able to tell anyone about it even at this time due to shame or indifference can then lead to more serious problems.

Chronically stored urine can stay in the bladder and cause a burning sensation when urinating, leading to infection.

Stored urine forms crystals. The crystals together form a stone in the bladder or kidney. The stones further clog the urethra.

Chronic urinary retention further weakens the bladder. The bladder also stores more urine. The volume of the bladder is 40 - 60 cubic liters. The volume of a coke bottle is 50 cubic liters. The bladder can increase up to 300 cubic liters as it stores more urine. The excessively filled bladder may leak, leading to wetting / urinary incontinence. Furthermore, this volume can put pressure on the kidneys and lead to kidney damage.

Bringing the man to the hospital is severe urinary retention. It is the inability of him to urinate when he wakes up one day and tries to urinate

Everything I described above is related to prostate enlargement, which is technically called benign prostate hyperplasia or BPH.

Other diseases of the prostate include:

1. Prostatitis - Inflammation of the prostate

2. Prostate cancer.

But here we can only look at prostate enlargement (BPH)

There is bad news and there is good news.

The bad news is that prostate enlargement is more common if every man lives longer.

The good news is that there are lifestyle changes that can help maintain optimal prostate health in men after the age of 40.

Nutrition / Diet: -

Watch what you eat. According to the American National Cancer Institute, 33% of all cancers are related to what we eat.

Every day consuming red meat triples your chances of prostate disease. Consuming milk every day doubles your risk. Not consuming fruits/vegetables daily increases your risk fourfold.

Tomatoes are very good for men. If the only thing your wife can offer in the evening, eat it with pleasure. It contains a lot of lycopene. Lycopene is a very powerful natural antioxidant.

Zinc-rich foods are also good for men. Pumpkin seeds can be recommended for zinc. (Ug Bogulu)

Zinc is the most important nutrient for male sexuality and fertility.

Men need more zinc than women. Each time a man loses 15 milligrams of zinc during ejaculation. Zinc is also important for alcohol metabolism. Your liver needs zinc to metabolize alcohol.

Alcohol consumption

When urinary symptoms associated with prostate enlargement begin to occur in men, it is important to monitor their alcohol consumption. Drinking more fluids will flush out more fluid.

Drink less. Or gradually stop drinking.

Exercise

Exercise helps build muscle tone. Every human being needs to exercise. Men over the age of 40 should avoid high-impact exercise such as jogging. This puts pressure on the knees. Cycling is bad news for the prostate. Can recommend a brisk walk.

Sitting

When we sit, two-thirds of our weight rests on the hips. Prostate symptoms are more common in men who sit for long periods of time. Do not sit for long. Walk as often as you can. Sit in comfortable chairs. You can use a detached saddle chair if you want to sit for a long time.

Wearing clothing

Men should avoid tight underwear. This affects the circulation around the waist and heats up slightly. While the physiological temperature is 37 degrees, the pelvis has an optimal temperature of about 33 degrees. Bond is not good for men. Wear thin loose-fitting ventilated clothing.

Smoking

Avoid smoking. It affects the blood vessels and affects the blood circulation around the waist.

Sex

Regular intercourse is good for the prostate.

Celibates are more prone to prostate disease. Although celibacy is a moral decision, it is not a biological health system. This is because your prostate gland is designed to constantly empty its contents.

Thought:

When someone shares a useful message like this with you and benefits from it. You have a moral obligation to share this with others because someone on your friends' list may be saved.

If you would like to comment on this article please post your comments in the comment box below

ANTI-DEPRESSANTS-3 MAO INHIBITORS-PARKINSON DISEASE-SELEGILINE-RASAGILINE

 Depression and Parkinson's Disease (PD)

Although this post is the third in a series of antidepressants, it is important to note that depression is one of the most common causes of Parkinson's disease.

Depression, anxiety, and psychoses are just like any other illness which just needs full support from the family. This is because dementia and Parkinson's Disease are often caused by unnecessary worries and depression.

MAO (MONO AMINE OXIDASE):-

Monoamine oxidase (MAO; EC 1.4.3.4.) is a mitochondrial enzyme system that is widely embedded in cells throughout the body, with high levels of exposure in gastrointestinal and liver, and neuronal tissues. This enzyme promotes the oxidative amino degradation of various types of monoamines and has the potential to break down any monoamine that is endogenous (produced inside the body) or exogenous (which can be a medicine given externally).

This enzyme disrupts and inactivates the monoamine neurotransmitters such as noradrenaline, dopamine, and serotonin, released for intercommunication of the neurons. Monoamine oxidase inhibitors, also known as MAOIs, are drugs that have been developed to inactivate this enzyme for neurodegenerative and depressive disorders such as Parkinson's Disease (PD).

MONOAMINE OXIDASE INHIBITORS(MAOIs)

These MAO enzyme inhibitors are of two types. They are MAOI-A and MAOI-B.

MAO-A and MAO-B inhibitors are in clinical use for the treatment of mental and neurological disorders (Parkinson's disease), respectively.

The clarity in studies of the active components of the molecules of these enzymes has led to the development of new compounds that inactivate these enzymes.

However, most of these enzyme inhibitors are irreversible. Although these are very decisive, the consequences are severe. So doctors do not prescribe many of these medications for depression now. However, they are still used especially for Parkinson's disease. Examples are Selegiline and Rasagiline.

The most important of these side effects is the Cheese Effect

People taking these drugs should avoid the following foods that may contain the amino acid tyramine. If not they may have complications such as heart attack and headaches. If you want to eat those foods you can take them a few hours after taking the medicine. However, it is better to consult a doctor.

Tyramine Foods

1. Chronic Stored Protein Foods (eg) Cheesecake, Meat

2.Chocolate

3. Citrus fruits, stored avocado (elephant guava), bananas, fruits such as raisins.

4.Pickles

5.Wine made from soaked grapes.

Sweets such as chocolate contain not only tyramine but also norepinephrine and serotonin. Taking all of these in combination with MAOI drugs can lead to a dangerous condition called 'Adrenergic or Hypertensive Crisis'.

MAO enzymes generally react and express their effects as follows.

     1             2      3             1A        2A       3A 

RCH2NH2+O2+H2O⟶RCHO+NH3↑+H2O2

                    MAOs  ↑

The above chemical equation can be explained as follows.

1.A monoamine

2.Oxygen.

3.Water

After MAO ↑ oxidation ()

1A. An aldehyde (toxic)

2A. Ammonia (toxic)

3.A. hydrogen peroxide (toxic)

All of the above toxins are caused by MAO oxidation. This condition can be caused by a number of illnesses, including depression. Under normal health, our body decomposes, detoxify and excrete these aldehyde and hydrogen peroxide toxins further by enzymes such as aldehyde dehydrogenase, catalase, and superoxide dismutase.

But this structure often collapses when subjected to frequent mental stresses, leading to Parkinson's and depressive disorders.

MAO Inhibitors (MAOIs) for Depression

These monoamine oxidase enzymes are classified as MAO-A and MAO-B. MAO-A can cause depression. It often targets neurotransmitters such as norepinephrine, adrenaline, and serotonin, that cause depression. The following medications disable this enzyme and relieve depression. But these should not be taken without a doctor's prescription. They are,

1.Isocarboxazid- (Marplan)-Nonselective &    Irreversible

2.Phenelzine     - (Nardil)--        do-

3.Selegiline      - (Selgin)-Irreversible & MAO-B-I

4.Rasagiline     -                            -do-

5.Safinamide    -              -Reversible & MAO-B-

6.Moclobemide -             -Reversible & MAO-A -

Of the drugs mentioned above, those labeled as Nonselective and  Irreversible have the potential to cause irreversible inaction of both the enzymes. They are very strong in action but have more side effects. So doctors do not recommend this much.

Those labeled as Selective and Irreversible have the ability to disable selectively and irreversibly either MAO-A or MAO-B. These are somewhat safer than the other. These include selegiline and rasagiline. These are used for Parkinson's disease.

Those labeled as Selective and Reversible have the ability to inactivate selectively and reversibly MAO-A or MAO-B.

These are safe but less effective. The new drugs in this category are safinamide and moclobemide. Of which safinamide is beneficial for Parkinson's disease and others for depressions.

MAO-B inhibitors are commonly used for Parkinson's disease. The reason is that MAO-B is the one that most often breaks down dopamine.

Parkinson's Disease and Dopamine: -

Fig-1
Dopamine Vs GABA

The basis of Parkinson's disease is the basal ganglia, the basic brain nucleus located at the center of the brain, the location of our intelligence and memory stability. Diseases such as Parkinson's and Alzheimer's occur when this area is affected (Fig-1).

In the picture above, is the basal ganglia and some of its parts mainly the striatum gland and the substantia nigra are shown. This has been where man's stability, organized movements, for example standing, sitting, responding to others with a moving facial expression, memory, intelligence, intellectual abilities, etc. are embedded.

Especially in this part of the human brain is being the rational wisdom and intelligence embedded.

All of the above will be jeopardized if this place is affected.

For example, if it is affected by high dopamine secretion, it can lead to Schizophrenia. Decreased dopamine secretion can lead to Parkinson's disease (see pictures above)

As you can see in the pictures above, dopamine flows from the substantia nigra to the striatum gland. In the picture, it is shown with a green curved arrow. Once it gets the dopamine it needs, the striatum gland secretes GABA to control the dopamine low. This is a continued cyclic process by nature.

Click here to read more about Parkinson's disease.

Parkinson's Disease -Continuity -Disease Symptoms, Treatment, and Warnings

 Symptoms, Treatment, and Warnings

BASAL GANGLIA (STRIATUM)
(DIAGRAMMATIC)

Parkinson's disease is a degenerative disorder of specific areas of the brain. It is characterized by muscle relaxation (tremor relaxation), increased muscle tone (stiffness), sluggishness of voluntary movements, and difficulty maintaining balance (post-instability). For many people, thinking becomes impaired, or senility develops.

Symptoms: -

The symptoms are rough and rhythmic.

1. Tremor when the hand is at rest (resting tremor)

2. Often the hand moves as it spins small objects (called tablet-rolls).

3. Decreases when the hand is intentionally moved and disappears completely during sleep

4. Emotional awakening may worsen due to stress or fatigue

Eventually next, switch to arms and legs

5. The most obvious symptom is a tremor that occurs when the muscles are relaxed.

6. Muscles become stiff, movements become slow and uncoordinated, balance is easily lost.

Parkinson's disease is the second most degenerative disorder of the central nervous system after Alzheimer's disease

Often the first sign of tremors is hand tremors. These tremors can be classified as follows: -

-Rough and rhythmic

Usually occurs in one hand when the hand is at rest (resting tremor)

-The hand moves as it often spins small objects (called tablet-rolls).

-Decreases when the hand is intentionally moved and disappears completely during sleep

-Emotional aggravation may be due to stress or fatigue

-Finally, this tremor may progress from one side to the arms and legs.

-It can affect the jaws, tongue, forehead, and eyelids, and to a lesser extent, it can affect the voice too.

It often affects the following People:-

1. 1 in 250 people over 40 years of age

2. 1 in 100 people aged 65 or over

3. 1 in 10 people aged 80 or over

Parkinson's disease usually begins between the ages of 50 and 79. Rarely, it occurs in children or adolescents.

Parkinsonism has symptoms similar to Parkinson's disease, but it can be caused by a variety of conditions, such as multiple organ degeneration of the body, progressive neuronal arthritis, stroke, head injury, or certain medications.

Stiffness:

Muscles stiffen and make movement difficult. When a doctor tries to bend or straighten the person's forearm or wrist, the hand resists moving, and when it moves, it starts and stops, as it is squeezed (called a cake wheel stiffness).

Slow movements:

The movements become slower and smaller and harder to start. Thus, people tend to move slowly. When they move slowly, it becomes difficult to move and it is very difficult to move as the joints and muscles weaken.

Difficulty maintaining balance and posture:

The posture is bent and it is difficult to maintain balance. Thus, the patient tends to invert forward or backward. Because the movements are slow, the patient is often unable to move their arms quickly to prevent them from falling down. These problems then develop into diseases.

Walking becomes difficult: -

 The patient will often retreat, especially after starting the first step. So he will take short steps. He bends his arms at the waist or dips his arms a little. While walking, some people have difficulty stopping or turning. As the disease progresses, some people will suddenly stop walking because they will feel like their feet are sticking to the ground (called frostbite). Others will accidentally and gradually accelerate their actions and enter the stumbling block.

Insomnia: -

Sleep problems, including insomnia, are common because people often have to urinate or have difficulty getting back to bed at night as symptoms worsen. Rapid-eye-movement (REM) sleep disorder usually develops. In this disorder, limbs that do not normally move during REM sleep can move suddenly and violently because people express their dreams, sometimes injuring the person lying next to them.

Insomnia can cause depression, weak thinking, and dizziness during the day.

Urinary problem: -

Problems with urination can occur. Urination can be difficult to begin and maintain (called urinary delay). People may have a compelling need to urinate (urgently). Disability is common.

Digestive system

Difficulty in swallowing may develop as the esophagus may move its contents too slowly. As a result, people may inhale oral secretions and/or the food they eat or the fluids they drink into the respiratory tract, which can cause pneumonia.

Constipation: - 

Because the intestine may move its contents slowly. Inactivity and levodopa, the main drug used to treat Parkinson's disease, can worsen constipation.

Orthostatic Hypotension: -

Sudden onset of hypotension when changing the posture from sitting to standing position (orthostatic hypotension)

Scales (seborrheic dermatitis): -

Most often develops on the scalp and face and occasionally on other areas.

Loss of smell (anosmia): - 

It is common, but people may not notice it.

Confusion :-( Dementia)

One-third of people with Parkinson's disease develop dementia, usually later in life. In many more, the thinking is weakened, but people may not recognize it.

Depression: -

 Sometimes people have problems with movements. Depression worsens as Parkinson's disease worsens. Depression can also make movement problems worse.

Hallucination

Hallucinations, delusions, and paranoia can occur, especially if dementia develops. People can see or hear things (illusions) that do not exist or hold firmly (illusions) despite clear evidence that contradicts certain beliefs. They may become hopeless and think that others are harming them (paranoia). These symptoms are considered psychiatric symptoms because they mean losing contact with reality.

Diagnosis of PD

-A physician's evaluation

-Sometimes computed tomography (CT scan) or magnetic resonance imaging (MRI) studies.

-Sometimes predicting whether levodopa is working properly.

People are more likely to develop Parkinson's disease if they have the following:

- Less, slower movements

- Tremor with a specific characteristic

- Muscle stiffness

-Clear and long-term (lasting) improvement in the effects of levodopa use

It is difficult for doctors to diagnose a mild, early disease because it usually begins with a technique. Diagnosis is especially difficult for the elderly.

Physical examination: -

During the physical examination, the doctor will ask the patient to perform certain movements, which will help confirm the diagnosis. For example, in people with Parkinson's disease, tremors disappear or subside when doctors ask them to touch the nose with their fingers. 

Also, sufferers find it difficult to make quick alternate movements such as placing their hands on their thighs and then quickly turning their hands back and forth several times.

Tests: -

No tests or imaging procedures can directly confirm the diagnosis. However, computed tomography (CT Scan) and magnetic resonance imaging (MRI Scan) can be done to diagnose a structural disorder that can cause symptoms. Common brain disorders of the disease can be detected by single-photon emission computed tomography (SPECT) and positron emission tomography (PET).

However, SPECT and PET are currently only used at the research level, and they do not distinguish Parkinson's disease from other disorders.

PD Treatments: -

-Common measures for managing symptoms

-Physical and occupational therapy

-Levodopa/carbidopa and other drugs

-Sometimes surgery (including deep brain stimulation)

-Common measures used to treat Parkinson's disease can help patients function better.

Many medications facilitate movement and help patients function effectively for many years to come.

Key features of treatment for Parkinson's disease: -

-Levodopa plus Carbidopa

-Other drugs are generally less effective than levodopa, but they may be beneficial for some people, especially when levodopa is ineffective or inadequate.

-However, no drug can cure the disease.

Two or more medications may be needed. For the elderly, doses are often reduced. Medications that cause or worsen symptoms, especially antipsychotic drugs, are avoided.

Medications used to treat Parkinson's disease can cause troublesome side effects. If people notice any abnormalities (such as difficulty or confusion in controlling the stimuli), they should report them to their doctor. They should not stop taking the medication until the doctor tells them to do so.

Deep Brain Stimulation: -

It is a surgical procedure that is only recommended if the patient has an advanced acute illness, but this treatment is not only ineffective for dementia or psychiatric symptoms and injuries caused by the use of certain psychiatric medications but can also cause serious side effects.

General Activities: -

-A variety of simple measures to help people with Parkinson's disease maintain mobility and independence:

-Continue daily activities as much as possible

-Regular exercise should be done regularly

-Facilitate daily tasks such as using fasteners or zippers in clothing and shoes.

Simple changes around the house can be safe for people with Parkinson's disease:

-Remove rugs to avoid stumble walking

-Install handrails in bathrooms and rails in hallways and other places to reduce the risk of falls.

-For constipation, the following may help:

-Eating high-fiber foods such as prunes and fruit juices

-Exercise

-Drinking plenty of fluids

-Using laxatives (such as senna, psyllium) or stimulant laxatives to keep bowel movements regular (such as oral bisacodyl)

-Difficulty in swallowing, can reduce food intake, so the food should be nutritious.

Doing more deep breathing exercises will improve the ability to smell and increase appetite.

Levodopa / Carbidopa

Traditionally, levodopa, given in combination with carbidopa, was the first drug used to treat Parkinson's disease. These medications, which can be taken orally, are an important part of the treatment for Parkinson's disease.

There is no truth in the claim that chronic levodopa use can exacerbate side effects and reduce its effectiveness. However, over time, Parkinson's disease can worsen in some people beyond levodopa usage.

Other medications that doctors may use include amantadine and dopamine agonists (drugs that stimulate dopamine receptors). Such drugs are used to increase dopamine production as it decreases in Parkinson's disease.

Levodopa reduces muscle stiffness, improves mobility, and significantly reduces tremors. Taking levodopa makes dramatic improvement for people with Parkinson's disease. This drug helps many people with mild illnesses to return to almost normal and some people who have been confined to bed can walk again.

Risk factors:-

-Brain damage caused by trauma in the past

-Injuries to the head from sports may increase the risk of this condition.

-Toxic exposure: Pesticides, solvents, metals, and other contaminants.

-Sex:-

 Men are 50% more likely to develop this condition than women, although a 2016 study suggests that the risk for women may also increase with age.

And this condition often appears from the age of 60s.

ANTI-DEPRESSANTS-AMITRIPTYLINE

AMITRIPTYLINE 

(Disclaimer: - The information included on this site is for educational purposes only and is not intended for medical treatment.)

Fig-1

This drug is available in pharmacies under the names ELIWEL, TRYPTOMER, and many other brands. They can be listed as follows.

Amichlor             Amitrol DS        Amilin

Amichlor-H         Amitrol              Eliwel

Amidon               Amixide             Emotrip

Amitone              Amixide-H         Libotryp

Librodep             Sarotena              Tadamit

                            Tryptomer

                            Tryptomer-SR

This drug is usually given for depression but is also prescribed by doctors as a pain reliever. Further, Although amitriptyline works through serotonin, it also acts through noradrenaline, unlike SSRI drugs (Figure-3). So although it is more powerful than SSRI drugs it has more side effects.

This prevents the reabsorption of not only serotonin but also other hormones between the nerve endings. So this cannot be called SSRI.

As for amitriptyline, it is used for depression but in very small doses it is also recommended by doctors as an analgesic.

Doctors rarely prescribe amitriptyline after the introduction of modern antidepressants such as SSRIs and SNRIs (We will see later about this in the headline SNRI)

USES

1. Depression (use approved by the drug control system)

2. Migraine.

3.Body and back pain

4.Diabetes neuropathy.

5.Nerve pains.

All of the above applications (2 to 5) are not approved by the Drug Administrations.

Side Effects:

1.Anticholinergic reactions.

2.The following α-adrenergic blocking reactions, viz

  Orthostatic Hypotension - A change in blood pressure 

 when the position is changed from a sitting position to a standing position

3. Weight gain

4. Insomnia.-Some doctors also prescribe it as a sleeping pill. But too much amitriptyline can cause insomnia. So focus.

5. Anorexia

6. Fatigue.-Doctors prescribe this medicine to stimulate the mind and body. But at the same time overuse can cause fatigue and tiredness in the body. So beware.

7.Nausea &Vomiting

Warnings

This drug should not be used spontaneously in the following conditions except under the supervision of a doctor.

1.Pregnancy period (especially the first trimester.

2. Breastfeeding period.

3.People with Kidney and Liver Disorder.

4.Patients with heart and blood pressure.

Other drug interactions with this drug: -

1. Do not take this with ulcer medicine like cisapride. Eating like that can damage the heart.

2.Quinidine drugs (heart disease)

3.SSRI Drugs,

(Examples) Fluoxetine (Flunil, Fludac)

             Paroxetine (Paxidep, Pexep)

             Fluvoxamine (Fluvoxin CR, Fluvator)

4.Quinapril (Q-press) -B.P. Drug

5.Chlorpheniramine, Phenylephrine (allergy and cold medicine)

6.Cimetidine-ulcer drug.

7.Zolpidem (Nightrest) -Sleeping.

We should not take amitriptyline with any of the above drugs.

Contraindications

Do not take amitriptyline under any of the following conditions:

1. Heart disease

2. Heart failure

3. Gallbladder disorder.

4. Liver disease

5. Irregular heartbeat

6. Heart attack

7.Kidney cancer

Frequently Asked Questions about Amitriptyline

1. Does this drug cause addiction?

Yes.

2 Is it possible to drive or operate heavy machinery after consuming this medicine?

Definitely not.

ANTI DEPRESSANTS- SSRI TYPE MEDICINES

 SEROTONIN SPECIFIC REUPTAKE INHIBITORS (SSRIs)

(Disclaimer: - The information included on this site is for educational purposes only and is not intended for medical treatment.)

Fig-1

For those who are depressed, the feelings of sadness are more intense. They cause chaos in their daily lives. This will make you unable to engage at home or at work. Feelings of depression can also lead to a variety of physical and emotional problems.

However, depression is one of the most easily cured mental disorders. But be a little mindful.80 to 90% of people benefit from some mental training in his endeavor. The mental exercises you need will depend on your specific situation, but for some, even though the medication may be very helpful, it is best to try as many mental exercises as possible.

Fig-2A

SSRIs for this depressive condition are now more commonly prescribed by doctors than any other type of medication. This is because they are safer than other drugs such as amitriptyline.

And according to a psychiatrist, this is due to chemical changes in the brain. That’s why he places more emphasis on drug therapy than mental training.

Fig-2B

How do SSRIs work?

Fig-3

SSRIs work by improving the function of nerve cells in the brain that control emotion. This serotonin helps in communication with signals between your brain cells. The chemicals that deliver these signals are called neurotransmitters. Serotonin is a type of neurotransmitter.

When these brain cells (called neurons) send signals to each other, they emit a little neurotransmitter to deliver the message. They then retrieve the released neurotransmitter. So that they can send the next message. This process of modifying the neurotransmitter is called "reuptake".

When you are struggling with depression, the areas of your brain that regulate mood, and send messages using serotonin, do not function properly. But these SSRIs make more serotonin available between neurons by inhibiting the "Reuptake Phenomenon Process". So neurons can send messages correctly between themselves. Therefore these drugs are called "Selective Serotonin Reuptake Inhibitors." or SSRIs.

Types of SSRIs: -

The following SSRIs are approved by the US FDA to treat depression, anxiety, and other mental disorders: -

• Citalopram (Celexa)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Fluvoxamine (Luvox, Luvox CR)
• Paroxetine (Paxil, Paxil CR)
• Sertraline (Zoloft)

• Vilazodone (Viibryd)

Side effects: -

Each type of medical treatment carries some risks. Possible side effects of these SSRI antidepressant medications include:

-Sleeplessness

-Headache

-Raw

-Blurred vision

-Dizzy

-Dry mouth

-Rebellion or anxiety

-Dizziness

-Pain in the joints or muscles

-Nausea or diarrhea

-Less sexual desire

-Erectile or ejaculation problems

-Some people, especially children, and young people are more likely to have suicidal thoughts when they regularly take SSRIs.

-There are also important security issues to consider about SSRIs. Although this is rare, if too much serotonin accumulates in your body, you may suffer from a condition called SEROTONIN SYNDROME. This often happens when two different serotonin-boosting drugs are taken together.

Warning: -

Some SSRIs can cause dangerous, side effects with other medications you take. They may be prescribed by a doctor or herbal and supplemental medications. Before starting an SSRI type of medicine, be sure to tell your doctor about all types of medications and supplements you are taking.

Because all SSRIs work the same way, the side effects are often the same no matter what type of medication you take. But each SSRI has a different chemical nature, so if one drug you take causes side effects, you can avoid many side effects if you switch to another drug with a doctor's permission.

While some have side effects, others do not. In many cases, the side effects disappear after a few weeks of treatment. You need to work with your doctor to find the right medicine for you.

How long does it take for the SSRI to be beneficial?

Changes are usually noticed 4 to 6 weeks after treatment. It can take months to realize the full effect of the medication.

If after 6 to 8 weeks you have no improvement, talk to your doctor about trying another treatment or adjusting your medication dose.

Termination of treatment: -

These drugs can have dangerous side effects when abruptly stopped or left unattended for several days. This is known as Discontinuation Syndrome or Withdrawal Syndrome.

You may start to feel like you have a fever. The following symptoms may occur too.

Nausea

-Dizziness

-Discomfort

-Fatigue or laziness

That is why, with the help of your doctor, it is important that you slowly reduce the dose he or she prescribes, and gradually discontinue the medication if you are advised that it is time to stop.

THOUGHT DISORDER-OBSESSIVE COMPULSIVE DISORDER

MANIA- OBSESSIVE-COMPULSIVE DISORDER(OCD)

(Disclaimer: - The information included on this site is for educational purposes only and is not intended for medical treatment.)

Fig-1

Are you the one who comes back ten times and pulls the lock to see if the house is locked properly?

Are you the one who comes back again and again when you leave the house locked and checks to see if the box and bureau inside are locked properly?

Do you wash your hands unnecessarily?

Are you repeating the same phrase unnecessarily during the conversation?

Are you unnecessarily disciplined?

Then you may have this thought disorder called OCD. This mental illness

You too will hate everything and everybody else and you too will feel hated by others. It can take you to the brink of despair and leave you with a sense of failure and a sense of suicide.

Many people with OCD know that their actions are unreasonable, but when they try to ignore the urge to do something, their anxiety increases until they are forced to do so.

That is, manic obsessive-compulsive disorder is a condition in which the problems we face at every stage of life and the experiences they cause us to become a disease that gradually penetrates our thoughts. This is called Obsessive-Compulsive Disorder (OCD) in medical parlance.

This can also be explained as follows. That is, a person may feel the urge to repeat certain thoughts ("obsessions" -obsession) or feel the need to repeat certain procedures ("compulsions" - compulsion). These stubborn thoughts and feelings will cause him great suffering or make him forget the most necessary things he has to do and ignore that process.

For example, he would sometimes miss the train in the process of repeatedly hand-washing and repeatedly checking that the box was locked. Also, he may miss his important daily routines too. Rarely does this condition take him to the peak of despair and even prepare him for suicide.

The disease affects not only adults but also young people and children.

In short, it involves people having repetitive, unwanted thoughts, ideas, or feelings (obsessions) that motivate them to do something over and over again (compulsions).

According to the National Institute of Mental Health, OCD affects 1% of adults in the United States alone. OCD does not discriminate and can affect anyone regardless of race, gender or age. It can have a profound effect on a person's quality of life and can affect their emotional health, education, career, and even their social and personal life, as their passions can lead to many hours of empty rituals.

Types of OCD:-

1.Dirt and washing it

2. Suspicion of accidental harm

3. Proper OCD - Symmetry, arrangement, and counting.

4. Unacceptable forbidden thoughts and mental rituals.

5. Mental pollution.

6. Hoarding

7. Rumors.

8.Invasive thoughts

Symptoms:

 The symptoms of OCD can be classified as follows.

- The inability to control one's behavior or thoughts, even when one realizes that his behavior is irrational.

He spends at least an hour every day in vain for such behaviors and thoughts

-He will perform some rituals to get short-term relief from tension (as opposed to desire and satisfaction)

Motor Tics or sudden repetitive movements (e.g.) Blinking, shoulder rolling, facial movement, shoulder or head shaking, moaning, murmuring.

Symptoms may subside or worsen over time. Some OCD sufferers prefer to stay away from things or situations that trigger their disorders. Others choose drugs, alcohol, or both to keep themselves calm.

Factors: -

1. Children, younger and older generations who are treated cruelly and unjustly.

2. Frequent stressors lead to depression.

3. Twins born in the same image with a genetic disorder.

4. Subject to repetitive fearful situations.

OCD-A PHYSIOLOGICAL DISORDER-A BRAIN DAMAGE

Fig-2A

Studies of OCD and related disorders suggest that OCD is caused by damage to a specific area of ​​the brain. This area is called the Basal Ganglia (Figure-2A).

The two brain structures that interact with the basal ganglia are the most active in OCD patients. Both of these structures are called the ORBITOFRONTAL CORTEX (OFC) and the Anterior Cingulate Gyrus (ACG). (Figure-2B)

Fig-2B

Treatments.-

 Cognitive-behavioral therapy: -

Creating a fearless atmosphere.

Behaving in such a way as to instill loving confidence in the patient.

Thereby dispelling the impulsive and frightening thoughts that arise in his mind, and finally changing the stubborn repetitive thoughts. This treatment cannot be done overnight. It may take many days, many months, and even many years. But this is a much better treatment than prescription pills. No after-effects. Do not need the help of a doctor.

Dangerous drug pill treatments.

In allopathy, what they say about this condition, is this is caused by a deficiency of the hormone serotonin in the central nervous system. 

Hence if we go to a psychiatrist for treatment of this disease, they mostly prescribe SSRI (SEROTONIN SPECIFIC REUPTAKE INHIBITORS) type antidepressants that turn us into permanent drug-addicted patients.

SSRIs and their side effects: -

All of these SSRI medicines damage the central nervous system and brain when eaten continuously. In addition, the autonomic nervous system is severely affected as follows.

1 Anticholinergic effect

2 Alpha-Adrenergic pressure elevation (caution for those with the prostate problem)

3.Increasing heart rate

4.Irregular heartbeat.

Details about SSRI can be found in the next post.

 Click here to continue watching the next post. Next post SSRI - to be continued .....